姓 名：卿志和

职 称：教授

导师资格：博士生导师

邮 箱：qingzhihe@hnu.edu.cn

电 话：0731-85258649

研究方向：生物传感与健康分析

简介：卿志和，教授，博士生导师，国家优秀青年科学基金获得者，“细胞化学”湖南省重点实验室常务副主任，“健康化学”湖南省普通高等学校科技创新团队带头人，登录入口“湖湘学者”拔尖人才、科技处副处长、化学化工学院教授委员会主任、化学生物学专业负责人，入选全球前2%顶尖科学家榜单。从事生物传感与健康分析研究工作，已主持国家自然科学基金优青项目、面上项目，湖南省自然科学基金重点项目、优青项目、企业技术服务项目等课题10余项，在 PNAS、Angew Chem、Anal Chem、等国内外高水平期刊上发表SCI收录论文80余篇，授权专利10余件。获得湖南省自然科学一等奖、湖南省自然科学二等奖、湖南省青年科技奖、湖南省教育系统优秀共产党员、湖南省优秀研究生导师等奖励或荣誉。担任Chinese Chemical Letters、The Innovation、Journal of Analysis and Testing、《分析试验室》等国内外期刊的编委或青年编委。

代表性论文：

[1] Quan Ke; Li Xiaoyuan; Deng Jiaqi; Chen Weiju; Zou Zhen; Chen Kun; Wu Linlin; Liu Juewen;Qing Zhihe*. Pt-Decorated Gold Nanoflares for High-Fidelity Phototheranostics: Reducing Side-Effects and Enhancing Cytotoxicity toward Target Cells, Angew. Chem. Int. Ed. 2024, 63, e202402881.

[2] Yanli Lei, Chuangchuang Li, Xinyue Ji, Haiyan Sun, Xiaowen Liu, Zenghui Mao, Weiju Chen, Zhihe Qing,* and Juewen Liu. Lowering Entropic Barriers in Triplex DNA Switches Facilitating Biomedical Applications at Physiological pH. Angew. Chem. Int. Ed. 2024, 63 , e202402123.

[3] Yibo Zhou, Zhengxuan Gu, Changhui Liu, Sheng Yang,* Xiaofei Ma, Qiaoshu Chen, Yanli Lei, Ke Quan, Juewen Liu, Zhihe Qing,* Ronghua Yang*. A Polymeric Nanobeacon for Revealing Hydrogen Polysulfides Fluctuation during Fertilization and Embryonic Development. Angew. Chem. Int. Ed. 2022, 61, e202114504.

[4] Zhen Zou, Libei He, Xiangxi Deng, Huangxiang Wang, Ziyun Huang, Qian Xue, Zhihe Qing*, Yanli Lei, Ronghua Yang*, and Juewen Liu. Zn2+-Coordination-Driven RNAAssembly with Retained Integrity and Biological Functions. Angew. Chem. Int. Ed. 2021, 60, 22970–22976.

[5] Lifang Chen, Shuohui Xing, Yanli Lei, Qiaoshu Chen, Zhen Zou, Ke Quan, Zhihe Qing*, Juewen Liu, and Ronghua Yang*. A Glucose-Powered Activatable Nanozyme Breaking pH and H2O2 Limitations for Treating Diabetic Infections. Angew. Chem. Int. Ed. 2021, 60, 23534–23539.

[6] Zhihe Qing, Guoyan Luo, Shuohui Xing, Zhen Zou, Yanli Lei, Juewen Liu*, Ronghua Yang*. Pt-S Bond Mediated Nanoflares for High-Fidelity Intracellular Applications by Avoiding Thiol Cleavage. Angew. Chem. Int. Ed.2020, 59, 14044 –14048.

[7] Zhihe Qing*, Jinlei Hu, Jingyuan Xu, Zhen Zou, Yanli Lei, Taiping Qing, Ronghua Yang*. An intramolecular catalytic hairpin assembly on a DNA tetrahedron for mRNA imaging in living cells: improving reaction kinetics and signal stability. Chem. Sci. 2020, 11, 1985–1990.

[8] Zhihe Qing*, Jingyuan Xu, Jing Zheng, Lei He, Zhen Zou, Sheng Yang, Weihong Tan, Ronghua Yang*. In Situ Amplification-Based Imaging of RNA in Living Cells. Angew. Chem. Int. Ed. 2019, 58, 11574–11585.