性别：男

最高学历：博士

系室：化学系

招生专业：化学、材料与化工、药学

QQ：1594093981

邮箱：008940@csust.edu.cn

教育背景及学习经历：

2021.07 – 2023.09      中国科学院杭州医学研究所             基础医学/博士后

2016.09 – 2021.05      湖南大学化学化工学院                   分析化学/博士

2014.09 – 2016.06      湖南大学化学化工学院                   分析化学/硕士

2010.09 – 2014.06      湖南中医药大学药学院                    药学/学士

科研情况：

◉ 主要研究方向：

1、生物医药与化学生物传感

2、纳米药物载体的构建与应用

3、靶向核药与抗体偶联药物肿瘤治疗

◉ 近5年科研项目：

1、国家自然科学基金青年项目，二级结构编码三链功能核酸耦合纳米孔技术及其在阿尔兹海默症早期筛查中的应用，执行时间：2022.01-2024.12；主持。

◉ 近5年科研论文：

1.Le Yang, Hongye Wei, Zhihe Qing, Linlin Wu. AuNP@DNA nanoflares: Preparation and application in bioanalysis and biomedicine, Chinese Chemical Letters. 2024, https://doi.org/10.1016/j.cclet.2024.110524. (SCI一区)

2. Le Yang, Zhihe Qing* Changhui Liu, Qiao Tang, Jishan Li, Sheng Yang, Jing Zheng, Ronghua Yang* and Weihong Tan. Direct fluorescent detection of blood potassium by ion-selective formation of intermolecular G-quadruplex and ligand binding. Analytical Chemistry, 2016, 88, 9285-9292. (SCI一区)

3. Le Yang†, Jing Zheng†, Zhen Zou, Haiyan Cai, Peng Qi, Zhihe Qing, Qi Yan, Liping Qiu, Weihong Tan and Ronghua Yang*. Human serum albumin as an intrinsic signal amplification amplifier for ultrasensitive assays of the prostate-specific antigen in human plasma. Chemical Communications, 2020, 56, 1834-1846. (SCI二区)

4. Liu, Jin†; Yang, Le†; Xue, Caoye†; Huang, Ge; Chen, Shiya; Zheng, Jing*; Yang, Ronghua ; Reductase and Light Programmatical Gated DNA Nanodevice for Spatiotemporally Controlled Imaging of Biomolecules in Subcellular Organelles under Hypoxic Conditions, ACS Applied Materials & Interfaces, 2021, 13(29): 33894-33904. (SCI一区)

5. Zhen Zou†, Xiaodou Liao†, Le Yang†, Ziyun Huang, Hua Yang, Qi Yan, Yufei Zhang, Zhihe Qing, Lihua Zhang, Feng Feng, and Ronghua Yang*. Human serum albumin-occupying-based fluorescence turn-on analysis of antiepileptic drug tiagabine hydrochloride. Analytical Chemistry, 2020, 92, 3535-3562. (SCI一区)

6. Qing Wei, Teng Yang, Jiayu Zhu, Ziwen Zhang, Le Yang, Yuchao Zhang, Can Hu, Jiahui Chen, Jinchao Wang, Xuefei Tian, Takaya Shimura, Jianmin Fang, Jieer Ying, Mengyang Fan, Peng Guo, Xiangdong Cheng. Spatiotemporal quantification of HER2-targeting antibody-drug conjugate bystander activity and enhancement of solid tumor penetration, Clinical Cancer Research. 2024, 30 (5): 984-997. (SCI一区)

教学情况:

主讲本科生《分析化学》、《分析化学实验》。